56) Charleston, MO

Located on I-57. The Lewis and Clark Bicentennial Visitor Center is located at Henry S. Whipple Park at the confluence of the Ohio and Mississippi River. The Center features a walk lined with plaques and the map of the expedition carved into granite rock.
57) Cape Girardeau, MO

57) Cape Girardeau, MO

On I-55. When the Corps of Discovery passed through in 1803, Cape Girardeau was already a thriving settlement. Meriwether Lewis met frontier trader Louis Lorimier at The Red House, a replica of which now serves as a downtown visitor center. The historic district comes...

58) Whittenberg, MO

This historic community east of Uniontown is near Tower Rock, the landmark on the Mississippi River that Lewis and Clark explored and measured in 1803.

59) St. Genevieve, MO

Off I-55 and US 61, was founded as a French colonial settlement and today has over 100 historic homes and structures housing galleries, wineries, and microbreweries.
60) St. Louis, MO

60) St. Louis, MO

At the crossroads of I-70, I-44, and I-55, Gateway Arch National Park marks the starting point of America’s westward exploration and the legacy of Meriwether Lewis and William Clark. The iconic Gateway Arch offers sweeping views of the Mississippi River, while the...